Companies operating in Mexico exist in an environment where cartels and drug trafficking pose persistent threats. Adding the risk of criminal prosecution to the mix for those companies, within its first months, the Trump administration has released multiple directives aimed at combating international criminal cartels. In this guest article, Miller & Chevalier members Maria Elena Lapetina and Katherine Pappas, with the assistance of visiting law clerk Manuela Jaramillo, discuss the Trump administration’s current approach to addressing cartel activity in Mexico; the intersection of shifting enforcement priorities and these cartel-related policies; and what companies operating in Mexico should be doing now to assess the potential impact of these initiatives. For more from Miller & Chevalier, see “Loose Lips Sink Ships: Maintaining Confidentiality in Investigations” (Nov. 20, 2024).